Neutrophil Adsorption by Polymyxin B-Immobilized Fiber Column for Acute Exacerbation in Patients with Interstitial Pneumonia: A Pilot Study

被引：51

作者：

Abe, Shinji ^{[1
]}

Seo, Yoshitsugu ^{[1
]}

Hayashi, Hiroki ^{[1
]}

Matsuda, Kuniko ^{[1
]}

Usuki, Jiro ^{[1
]}

Azuma, Arata ^{[1
]}

Kudoh, Shoji ^{[1
]}

Gemma, Akihiko ^{[1
]}

机构：

[1] Nippon Med Sch, Dept Pulm Med Infect & Oncol, Tokyo 1138603, Japan

来源：

BLOOD PURIFICATION | 2010年 / 29卷 / 04期

关键词：

Acute exacerbation; Diffuse alveolar damage; Idiopathic pulmonary fibrosis; Interstitial pneumonia; Neutrophil adsorption; Polymyxin B-immobilized fiber column; IDIOPATHIC PULMONARY-FIBROSIS; DIRECT HEMOPERFUSION; SEPSIS;

D O I：

10.1159/000287232

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background/Aims: Polymyxin B-immobilized fiber (PMX) treatment has beneficial effects in patients with acute lung injury/acute respiratory distress syndrome or acute exacerbation of idiopathic pulmonary fibrosis. This study was aimed to clarify the mechanism of PMX treatment for acute exacerbation of interstitial pneumonia (IP). Materials and Methods: Sixteen consecutive IP patients with acute exacerbation were included. The patients were treated with PMX once daily for 2 successive days at a flow rate of 80-100 ml/min for 6 h. Cells adsorbed by PMX were analyzed morphologically by electron microscopy. Surface markers of these cells were determined by flow cytometry. Serum matrix metalloproteinase (MMP)-9 was measured before and after PMX treatment. Results: Cells adsorbed by PMX were neutrophils and highly expressed HLA-DR, CD14, CD62L and CD114. Serum MMP-9 levels were significantly decreased after PMX treatment. Conclusion: This pilot study demonstrated neutrophil adsorption by PMX and its possible clinical application for acute exacerbation of IP. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：321 / 326

页数：6

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