Covariation of Major and Minor Viral Capsid Proteins in Norovirus Genogroup II Genotype 4 Strains

被引：23

作者：

Chan, Martin Chi-Wai ^{[1
]}

Lee, Nelson ^{[2
]}

Ho, Wing-Shan ^{[1
,2
]}

Law, Carmen Oi-Kwan ^{[1
]}

Lau, Terrence Chi-Kong ^{[3
,4
]}

Tsui, Stephen Kwok-Wing ^{[3
]}

Sung, Joseph Jao-Yiu ^{[1
,2
]}

机构：

[1] Chinese Univ Hong Kong, Inst Digest Dis, Hong Kong, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China

[4] City Univ Hong Kong, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R China

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 02期

关键词：

FELINE CALICIVIRUS VP2; NORWALK-LIKE VIRUSES; HONG-KONG; ORF3; GASTROENTERITIS;

D O I：

10.1128/JVI.00228-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report sequence hypervariability in the viral protein 1 (VP1) interaction domain of VP2 in the norovirus (NoV) genogroup II genotype 4 (GII.4) lineage on 3 levels: (i) the global evolution of pandemic/epidemic strains from the mid-1970s through post-2006, (ii) the local emergence of an epidemic strain, and (iii) an immunocompromised patient chronically shedding NoV. When a quantitative yeast two-hybrid assay was used, VP2 was found to interact with VP1 in a time-ordered, strain-dependent manner among 3 NoV GII.4 strains. Our findings suggest that VP1 and VP2 may covary in virus evolution and that sequence hypervariability of VP2 may be functionally driven. Further investigations are warranted.

引用

页码：1227 / 1232

页数：6

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