Cohort profile: a prospective Australian cohort study of women's reproductive characteristics and risk of chronic disease from menarche to premenopause (M-PreM)

被引：10

作者：

Chan, Hsiu-Wen ^{[1
]}

Dharmage, Shyamali ^{[2
]}

Dobson, Annette ^{[1
]}

Chung, Hsin-Fang ^{[1
]}

Loxton, Deborah ^{[3
]}

Doust, Jenny ^{[1
]}

Montgomery, Grant ^{[4
]}

Stamatakis, Emmanuel ^{[5
]}

Huxley, Rachel R. ^{[6
,7
]}

Hamer, Mark ^{[8
]}

Abbott, Jason ^{[9
,10
]}

Yeap, Bu Beng ^{[11
,12
]}

Visser, Jenny A. ^{[13
]}

McIntyre, Harold ^{[14
,15
]}

Mielke, Gregore Iven ^{[1
]}

Mishra, Gita D. ^{[1
]}

机构：

[1] Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia

[2] Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Carlton, Vic, Australia

[3] Univ Newcastle, Ctr Womens Hlth Res, Newcastle, NSW, Australia

[4] Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia

[5] Univ Sydney, Charles Perkins Ctr, Sydney, NSW, Australia

[6] Deakin Univ, Fac Hlth, Burwood, Vic, Australia

[7] Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia

[8] UCL, Fac Med Sci, Div Surg & Intervent Sci, London, England

[9] Univ New South Wales, Sch Womens & Childrens Hlth, Sydney, NSW, Australia

[10] Royal Hosp Women, Gynaecol Res & Clin Evaluat GRACE Unit, Sydney, NSW, Australia

[11] Univ Western Australia, Med Sch, Perth, WA, Australia

[12] Fiona Stanley Hosp, Dept Endocrinol & Diabet, Perth, WA, Australia

[13] Univ Med Ctr, Dept Internal Med, Erasmus MC, Rotterdam, Netherlands

[14] Univ Queensland, Sch Med, Brisbane, Qld, Australia

[15] Univ Queensland, Mater Res, Brisbane, Qld, Australia

来源：

BMJ OPEN | 2022年 / 12卷 / 10期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

PUBLIC HEALTH; Hypertension; EPIDEMIOLOGY; Asthma; MONTREAL COGNITIVE ASSESSMENT; POLYCYSTIC-OVARY-SYNDROME; PHYSICAL-ACTIVITY; BLOOD-PRESSURE; NORMATIVE DATA; HEALTH; ASTHMA; AGE; METAANALYSIS; PREVALENCE;

D O I：

10.1136/bmjopen-2022-064333

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Purpose Previous studies have identified associations between individual reproductive factors and chronic disease risk among postmenopausal women. However, few have investigated the association of different markers of reproductive function, their interactions and risk factors of chronic disease among women approaching menopause. The Menarche-to-PreMenopause (M-PreM) Study aims to examine the relationship between reproductive factors across the reproductive lifespan and risk indicators for chronic disease among women in their early-to-mid-40s. The purpose of this cohort profile paper is to describe the rationale, study design and participant characteristics of the M-PreM Study. Participants Women born in 1973-1978 who participated in the Australian Longitudinal Study on Women's Health (ALSWH) were invited to undertake a clinical or self-administered assessment. A total of 1278 women were recruited from June 2019 to June 2021. Findings to date The study measures included functional, cognitive and cardiometabolic tests, anthropometry, spirometry, respiratory health questionnaires, physical activity, sleep patterns, sex hormones, and cardiovascular and metabolic markers; whereas blood and saliva samples were used for the analysis of genetic variants of genes associated with reproductive characteristics and chronic disease. The mean age of the clinic and self-assessed participants was 44.6 and 45.3 years, respectively. The menopausal status of participants was similar between the two arms of the study: 38%-41% premenopausal, 20% perimenopausal, and 36% took oral contraception or hormone replacement therapy. Approximately 80% of women had at least one child and participants reported experiencing pregnancy complications: preterm birth (8%-13% of pregnancies), gestational diabetes (10%) and gestational hypertension (10%-15%). Future plans The biomedical data collected in the M-PreM Study will be linked to existing ALSWH survey data on sociodemographic factors, health behaviour, reproductive function, and early life factors collected over the past 20 years and health administrative data. The association between reproductive factors and risk indicators of chronic disease will be analysed.

引用

页数：12

共 46 条

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