Acute kidney injury: Definitions and new paradigms

被引:34
作者
Endre, Zoltan H. [1 ]
机构
[1] Univ Otago, Dept Med, Christchurch, New Zealand
关键词
acute kidney injury; definition; staging; biomarkers; treatment of AKI;
D O I
10.1053/j.ackd.2008.04.002
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Changes in terminology and new consensus definitions of acute kidney injury (AKI) and stages of severity have simplified some of the problems in the clinical approach to this complex syndrome. Nevertheless, new proactive approaches to the diagnosis of kidney injury instead of kidney failure are required to allow clinical translation of successful therapies developed for experimental AKI. The recent development of novel urinary and plasma biomarkers, which predict kidney failure, has allowed the development of new paradigms for detection, prevention, and stage-specific treatment. (C) 2008 by the National Kidney Foundation, Inc. All rights reserved.
引用
收藏
页码:213 / 221
页数:9
相关论文
共 63 条
[21]   Prognostic value of tubular proteinuria and enzymuria in nonoliguric acute tubular necrosis [J].
Herget-Rosenthal, S ;
Poppen, D ;
Hüsing, J ;
Marggraf, G ;
Pietruck, F ;
Jakob, HG ;
Philipp, T ;
Kribben, A .
CLINICAL CHEMISTRY, 2004, 50 (03) :552-558
[22]  
Herget-Rosenthal S, 2005, CLIN NEPHROL, V64, P41
[23]   Multicenter clinical trial of recombinant human insulin-like growth factor I in patients with acute renal failure [J].
Hirschberg, R ;
Kopple, J ;
Lipsett, P ;
Benjamin, E ;
Minei, J ;
Albertson, T ;
Munger, M ;
Metzler, M ;
Zaloga, G ;
Murray, M ;
Lowry, S ;
Conger, J ;
McKeown, W ;
O'Shea, M ;
Baughman, R ;
Wood, K ;
Haupt, M ;
Kaiser, R ;
Simms, H ;
Warnock, D ;
Summer, W ;
Hintz, R ;
Myers, B ;
Haenftling, K ;
Capra, W ;
Pike, M ;
Guler, HP .
KIDNEY INTERNATIONAL, 1999, 55 (06) :2423-2432
[24]   The early biomarker of acute kidney injury: in search of the Holy Grail [J].
Honore, Patrick M. ;
Joannes-Boyau, Olivier ;
Boer, Willem .
INTENSIVE CARE MEDICINE, 2007, 33 (11) :1866-1868
[25]   RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis [J].
Hoste, Eric A. J. ;
Clermont, Gilles ;
Kersten, Alexander ;
Venkataraman, Ramesh ;
Angus, Derek C. ;
De Bacquer, Dirk ;
Kellum, John A. .
CRITICAL CARE, 2006, 10 (03)
[26]   Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury [J].
Ichimura, T ;
Hung, CC ;
Yang, SA ;
Stevens, JL ;
Bonventre, JV .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2004, 286 (03) :F552-F563
[27]   Pharmacologic treatment of acute kidney injury: why drugs haven't worked and what is on the horizon [J].
Jo, Sang Kyung ;
Rosner, Mitchell H. ;
Okusa, Mark D. .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2007, 2 (02) :356-365
[28]   Delayed administration of darbepoetin or erythropoietin protects against ischemic acute renal injury and failure [J].
Johnson, D. W. ;
Pat, B. ;
Vesey, D. A. ;
Guan, Z. ;
Endre, Z. ;
Gobe, G. C. .
KIDNEY INTERNATIONAL, 2006, 69 (10) :1806-1813
[29]  
Lameire N, 2005, LANCET, V365, P417
[30]  
Lameire Norbert, 2004, Curr Opin Crit Care, V10, P468, DOI 10.1097/01.ccx.0000144939.24897.71