A structural informatics study on collagen

被引：5

作者：

Bolboacaa, Sorana D. ^{[1
]}

Jaentschi, Lorentz ^{[2
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Dept Med Informat & Biostat, Cluj Napoca, Romania

[2] Tech Univ Cluj Napoca, Cluj Napoca 400641, Romania

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2008年 / 71卷 / 02期

关键词：

amino acids; structure-activity relationships; type I collagen;

D O I：

10.1111/j.1747-0285.2007.00619.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The study integrates knowledge resulting from structure-activity relationships analysis of amino acids with respect to the characterization of alpha 1 and alpha 2 type I collagen chains. Specifically, 15 amino acids and 14 properties were investigated and their structure-activity relationship models were obtained. The models were integrated into a web application and were used to predict the properties of a set of six amino acids. The similarities in alpha 1 and alpha 2 type I collagen chains has been investigated starting from the observed and predicted properties of amino acids by using two-step cluster analysis.

引用

页码：173 / 179

页数：7

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