Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression

被引:175
作者
Krishnan, KRR
Taylor, WD
McQuoid, DR
MacFall, JR
Payne, ME
Provenzale, JM
Steffens, DC
机构
[1] Duke Univ, Med Ctr, Dept Psychiat, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA
关键词
depression; aged; MRI; cerebrovascular disease; diagnostic criteria;
D O I
10.1016/j.biopsych.2003.08.014
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: There is a substantial body of research supporting the vascular depression hypothesis of late-life depression. To update this hypothesis so it incorporates recent research, we propose that the term subcortical ischemic vascular depression may be a more accurate representation of the disease process. We sought to investigate this diagnosis as a construct by examining differences between depressed subjects with and without magnetic resonance imaging defined subcortical ischemic vascular depression. Methods. This case-control study examined 139 depressed elderly subjects. Demographic data, psychiatric, medical, and family history, depressive symptomatology, and functional impairment were compared between groups dichotomized based on neuroimaging findings. Results: Seventy-five (54%) of the subjects met neuroimaging criteria for subcortical ischemic vascular depression. Age was most strongly associated with increased prevalence of subcortical ischemic vascular depression. Lassitude and a history of hypertension were also positively associated with the diagnosis; a family history of mental illness and loss of libido were negatively associated with the diagnosis. Conclusions. These data support that subcortical ischemic vascular depression may be a specific syndrome from other types of late-life depression. Further research is needed to further characterize this disorder. particularly in regards to cognitive junction and treatment implications.
引用
收藏
页码:390 / 397
页数:8
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