CREB-1 and CREB-2 immunoreactivity in the rat brain

被引：17

作者：

Ferrer, I ^{[1
]}

Blanco, R ^{[1
]}

Rivera, R ^{[1
]}

Carmona, M ^{[1
]}

Ballabriga, J ^{[1
]}

Olive, M ^{[1
]}

Planas, AM ^{[1
]}

机构：

[1] CSIC,CID,DEPT FARMACOL & TOXICOL,E-08034 BARCELONA,SPAIN

来源：

BRAIN RESEARCH | 1996年 / 712卷 / 01期

关键词：

cyclic response element-binding protein; kainic acid; gene transcription; astrocyte;

D O I：

10.1016/0006-8993(95)01527-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study is focused to learn about the cellular localization of transcription factors binding to the cAMP response element-CREBs-in the brain of normal rats and in animals subjected to excitotoxic cell damage. For this purpose, CREB-1 and CREB-2 immunoreactivity is examined in the developing and adult rat brain under physiological conditions, and following systemic kainic acid (KA) injection at convulsant doses in the adult, as a validated experimental model of excitotoxic injury. CREB-1 immunoreactivity is constitutively expressed in periventricular glia and Bergmann glia, and appears in reactive astrocytes following KA-induced excitotoxic cell damage. In contrast, CREB-2 is constitutively expressed in all neurons of the cerebrum, cerebellum and brain stem in the developing and adult brain. CREB-2 immunoreactivity is not increased following KA excitotoxic cell damage. These results demonstrate that CREB-1 and CREB-2 in the brain of the rat are localized in separate cellular compartments and that their expression is differentially regulated in pathologic states.

引用

页码：159 / 164

页数：6

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