Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer

被引：298

作者：

Gudmundsson, Julius ^{[1
]}

Sulem, Patrick ^{[1
]}

Rafnar, Thorunn ^{[1
]}

Bergthorsson, Jon T. ^{[1
]}

Manolescu, Andrei ^{[1
]}

Gudbjartsson, Daniel ^{[1
]}

Agnarsson, Bjarni A. ^{[2
]}

Sigurdsson, Asgeir ^{[1
]}

Benediktsdottir, Kristrun R. ^{[2
]}

Blondal, Thorarinn ^{[1
]}

Jakobsdottir, Margret ^{[1
]}

Stacey, Simon N. ^{[1
]}

Kostic, Jelena ^{[1
]}

Kristinsson, Kari T. ^{[1
]}

Birgisdottir, Birgitta ^{[1
]}

Ghosh, Shyamali ^{[1
]}

Magnusdottir, Droplaug N. ^{[1
]}

Thorlacius, Steinunn ^{[1
]}

Thorleifsson, Gudmar ^{[1
]}

Zheng, S. Lilly ^{[3
]}

Sun, Jielin ^{[3
]}

Chang, Bao-Li ^{[3
]}

Elmore, J. Bradford ^{[4
]}

Breyer, Joan P. ^{[4
]}

McReynolds, Kate M. ^{[4
]}

Bradley, Kevin M. ^{[4
]}

Yaspan, Brian L. ^{[4
]}

Wiklund, Fredrik

Stattin, Par ^{[6
]}

Lindstrom, Sara ^{[5
]}

Adami, Hans-Olov ^{[5
,7
]}

McDonnell, Shannon K. ^{[8
]}

Schaid, Daniel J. ^{[8
]}

Cunningham, Julie M. ^{[9
]}

Wang, Liang ^{[9
]}

Cerhan, James R. ^{[8
]}

St Sauver, Jennifer L. ^{[8
]}

Isaacs, Sara D. ^{[10
]}

Wiley, Kathleen E. ^{[10
]}

Partin, Alan W. ^{[10
]}

Walsh, Patrick C. ^{[10
]}

Polo, Sonia ^{[11
]}

Ruiz-Echarri, Manuel ^{[12
]}

Navarrete, Sebastian ^{[13
]}

Fuertes, Fernando ^{[13
]}

Saez, Berta ^{[14
,15
]}

Godino, Javier ^{[14
]}

Weijerman, Philip C. ^{[16
]}

Swinkels, Dorine W. ^{[17
]}

Aben, Katja K. ^{[18
,19
]}

机构：

[1] deCODE Genet, IS-101 Reykjavik, Iceland

[2] Landspitali Univ Hosp, Dept Pathol, IS-101 Reykjavik, Iceland

[3] Wake Forest Univ, Sch Med, Ctr Human Genome, Winston Salem, NC 27157 USA

[4] Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Dept Med, Nashville, TN 37232 USA

[5] Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden

[6] Umea Univ Hosp, Dept Urol, S-90185 Umea, Sweden

[7] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[8] Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA

[9] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA

[10] Johns Hopkins Med Inst, Brady Urol Inst, Baltimore, MD 21209 USA

[11] Quiron Hosp, Div Radiat Oncol, Zaragoza 50009, Spain

[12] Univ Zaragoza, Lozano Blesa Univ Hosp, Div Med Oncol, E-50009 Zaragoza, Spain

[13] Univ Zaragoza, Lozano Blesa Univ Hosp, Div Radiat Oncol, E-50009 Zaragoza, Spain

[14] Hlth Sci Inst, Zaragoza 50009, Spain

[15] Nanotechnol Inst Aragon, Zaragoza 50009, Spain

[16] Rijinstate Hosp, Dept Urol, NL-6800 TA Arnhem, Netherlands

[17] Radboud Univ Nijmegen, Med Ctr, Dept Clin Chem, NL-6500 HB Nijmegen, Netherlands

[18] Comprehens Canc Ctr E, NL-6501 BG Nijmegen, Netherlands

[19] Radboud Univ Nijmegen, Dept Epidemiol & Biostat, Med Ctr, NL-6500 HB Nijmegen, Netherlands

[20] Radboud Univ Nijmegen, Med Ctr, Dept Urol, NL-6500 HB Nijmegen, Netherlands

[21] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

[22] Northwestern Univ, Feinberg Sch Med, Dept Urol, Chicago, IL 60611 USA

[23] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA

[24] Landspitali Univ Hosp, Dept Urol, Reykjavik 101, Iceland

[25] VA Tennessee Valley Hlthcare Syst, Med Res Serv, Nashville, TN 37212 USA

来源：

NATURE GENETICS | 2008年 / 40卷 / 03期

关键词：

D O I：

10.1038/ng.89

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.

引用

页码：281 / 283

页数：3

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