Constituents of Hypericum laricifolium and their cyclooxygenase (COX) enzyme activities

被引：40

作者：

El-Seedi, HR ^{[1
]}

Ringbom, T ^{[1
]}

Torssell, K ^{[1
]}

Bohlin, L ^{[1
]}

机构：

[1] Univ Uppsala, Div Pharmacognosy, Dept Med Chem, Biomed Ctr, SE-75123 Uppsala, Sweden

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2003年 / 51卷 / 12期

关键词：

Hypericum laricifolium; Guttiferae; caffeate ester; flavonol; cyclooxygenase-1 (COX-1); cyclooxygenase-2 (COX-2);

D O I：

10.1248/cpb.51.1439

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Investigation of the aerial parts of the medicinal plant Hypericum laricifolium led to the isolation of two new natural products, hentriacontanyl caffeate (1a), nonacosanyl caffeate (1b). In addition, stigmasterol, P-sitosterol, 3-epi-betulinic acid (2), caffeic acid (3), ferulic acid, docosanol, p-hydroxybenzoic acid, 3,4-dimethoxy benzoic acid, quercetin (4), quercetin-3-O-galactoside (5), quercetin-3-O-rutinoside (6), quercetin-3-O-rhamnoside (7), quercetin-3-O-glucuronide (8) and shikimic acid were also isolated. The structures were determined by 1D- and 2D-NMR, mass spectrometry, and chemical transformations. The anti-inflammatory effects of the isolated compounds were discussed briefly.

引用

页码：1439 / 1440

页数：2

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