Paramecium genome survey:: a pilot project

被引：50

作者：

Dessen, P

Zagulski, M

Gromadka, R

Plattner, H

Kissmehl, R

Meyer, E

Bétermier, M

Schultz, JE

Linder, JU

Pearlman, RE

Kung, C

Forney, J

Satir, BH

Van Houten, JL

Keller, AM

Froissard, M

Sperling, L

Cohen, J

机构：

[1] CNRS, UMS825, INSERM, SC13,Serv Bioinformat, F-94801 Villejuif, France

[2] Polish Acad Sci, Inst Biochem & Biophys, DNA Sequencing Lab, PL-02106 Warsaw, Poland

[3] Univ Constance, Dept Biol, D-78457 Constance, Germany

[4] Ecole Normale Super, Genet Mol Lab, F-75005 Paris, France

[5] Univ Tubingen, Sch Pharm, Sect Pharmaceut Biochem, D-72076 Tubingen, Germany

[6] York Univ, Dept Biol, Core Mol Biol Facil, Toronto, ON M3J 1P3, Canada

[7] Univ Wisconsin, Mol Biol Lab, Madison, WI 53706 USA

[8] Purdue Univ, W Lafayette, IN 47907 USA

[9] Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA

[10] Univ Vermont, Dept Biol, Burlington, VT 05405 USA

[11] CNRS, Ctr Genet Mol, F-91198 Gif Sur Yvette, France

来源：

TRENDS IN GENETICS | 2001年 / 17卷 / 06期

关键词：

D O I：

10.1016/S0168-9525(01)02307-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A consortium of laboratories undertook a pilot sequencing project to gain insight into the genome of Paramecium. Plasmid-end sequencing of DNA fragments from the somatic nucleus together with similarity searches identified 722 potential protein-coding genes. High gene density and uniform small intron size make random sequencing of somatic chromosomes a cost-effective strategy for gene discovery in this organism.

引用

页码：306 / 308

页数：3

共 26 条

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