Vitamin D3: a helpful immuno-modulator

被引：343

作者：

Di Rosa, Michelino ^{[1
]}

Malaguarnera, Michele ^{[2
]}

Nicoletti, Ferdinando ^{[1
]}

Malaguarnera, Lucia ^{[1
]}

机构：

[1] Univ Catania, Dept Biomed Sci, Catania, Italy

[2] Univ Catania, Dept Biol Chem Med Chem & Mol Biol, Catania, Italy

来源：

IMMUNOLOGY | 2011年 / 134卷 / 02期

关键词：

adaptive immunity; immune cells; immunoregulation; innate immunity; vitamin D3; REGULATORY T-CELLS; CATHELICIDIN ANTIMICROBIAL PEPTIDE; D-RECEPTOR; 1,25-DIHYDROXYVITAMIN D-3; DENDRITIC CELLS; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; MYCOBACTERIUM-TUBERCULOSIS; D DEFICIENCY; MACROPHAGE DIFFERENTIATION; GENETIC SUSCEPTIBILITY;

D O I：

10.1111/j.1365-2567.2011.03482.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The active metabolite of vitamin D, 1 alpha, 25-dihydroxyvitamin D3 [1,25(OH)(2)D3], is involved in calcium and phosphate metabolism and exerts a large number of biological effects. Vitamin D3 inhibits parathyroid hormone secretion, adaptive immunity and cell proliferation, and at the same time promotes insulin secretion, innate immunity and stimulates cellular differentiation. The role of vitamin D3 in immunoregulation has led to the concept of a dual function as both as an important secosteroid hormone for the regulation of body calcium homeostasis and as an essential organic compound that has been shown to have a crucial effect on the immune responses. Altered levels of vitamin D3 have been associated, by recent observational studies, with a higher susceptibility of immune-mediated disorders and inflammatory diseases. This review reports the new developments with specific reference to the metabolic and signalling mechanisms associated with the complex immune-regulatory effects of vitamin D3 on immune cells.

引用

页码：123 / 139

页数：17

共 157 条

[1] 1-ALPHA,25-DIHYDROXYVITAMIN-D3 PROMOTES FUSION OF MOUSE ALVEOLAR MACROPHAGES BOTH BY A DIRECT MECHANISM AND BY A SPLEEN CELL-MEDIATED INDIRECT MECHANISM [J].