IRL 2500: A potent ET(B) selective endothelin antagonist

被引：11

作者：

Fruh, T

Saika, H

Svensson, L

Pitterna, T

Sakaki, J

Okada, T

Urade, Y

Oda, K

Fujitani, Y

Takimoto, M

Yamamura, T

Inui, T

Makatani, M

Takai, M

Umemura, I

Teno, N

Toh, H

Hayakawa, K

Murata, T

机构：

[1] CIBA GEIGY LTD,INT RES LABS,TAKARAZUKA,HYOGO 665,JAPAN

[2] BIOMOL ENGN RES INST,SUITA,OSAKA 565,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 19期

关键词：

D O I：

10.1016/0960-894X(96)00421-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Combination of a glycine substitution scan on the C-terminal dodecapeptide analog of ET-1 and a substance P antagonist screen on the basis of a homology study of the rhodopsin superfamily of seven-transmembrane receptors yielded in the development of IRL 2500, a potent ET(B) selective endothelin antagonist. Copyright (C) 1996 Published by Elsevier Science Ltd

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页码：2323 / 2328

页数：6

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