Diversity in cell surface sialic acid presentations: implications for biology and disease

被引：412

作者：

Varki, Nissi M.

Varki, Ajit

机构：

[1] Univ Calif San Diego, Glycobiol Res & Training Ctr, Dept Pathol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA

来源：

LABORATORY INVESTIGATION | 2007年 / 87卷 / 09期

关键词：

D O I：

10.1038/labinvest.3700656

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Sialic acids (Sias) are typically found as terminal monosaccharides attached to cell surface glycoconjugates. They play many important roles in many physiological and pathological processes, including microbe binding that leads to infections, regulation of the immune response, the progression and spread of human malignancies and in certain aspects of human evolution. This review will provide some examples of these diverse roles of Sias and briefly address immunohistochemical approaches to their detection.

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页码：851 / 857

页数：7

相关论文

共 53 条

[11] Detection of sialic acids and gangliosides with special reference to 9-O-acetylated species in basaliomas and normal human skin [J].

Fahr, C ;

Schauer, R .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2001, 116 (02) :254-260

[12] Human-specific regulation of α2-6-linked sialic acids [J].

Gagneux, P ;

Cheriyan, M ;

Hurtado-Ziola, N ;

van der Linden, ECMB ;

Anderson, D ;

McClure, H ;

Varki, A ;

Varki, NM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (48) :48245-48250

[13] THE RECEPTOR-DESTROYING ENZYME OF INFLUENZA-C VIRUS IS NEURAMINATE-O-ACETYLESTERASE [J].

HERRLER, G ;

ROTT, R ;

KLENK, HD ;

MULLER, HP ;

SHUKLA, AK ;

SCHAUER, R .

EMBO JOURNAL, 1985, 4 (06) :1503-1506

[14]

HIGASHI H, 1985, CANCER RES, V45, P3796

[15]

Ilver D, 2003, METHOD ENZYMOL, V363, P134

[16] An unusual carbohydrate binding site revealed by the structures of two Maackia amurensis lectins complexed with sialic acid-containing oligosaccharides [J].

Imberty, A ;

Gautier, C ;

Lescar, J ;

Pérez, S ;

Wyns, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (23) :17541-17548

[17] 9-O-ACETYLATED SIALIC ACIDS HAVE WIDESPREAD BUT SELECTIVE EXPRESSION - ANALYSIS USING A CHIMERIC DUAL-FUNCTION PROBE DERIVED FROM INFLUENZA-C HEMAGGLUTININ-ESTERASE [J].

KLEIN, A ;

KRISHNA, M ;

VARKI, NM ;

VARKI, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (16) :7782-7786

[18]

KNIBBS RN, 1993, J BIOL CHEM, V268, P18524

[19] Gangliosides with O-acetylated sialic acids in tumors of neuroectodermal origin [J].

Kohla, G ;

Stockfleth, E ;

Schauer, R .

NEUROCHEMICAL RESEARCH, 2002, 27 (7-8) :583-592

[20] DIFFERENTIAL DISTRIBUTION OF MAJOR GANGLIOSIDES IN RAT CENTRAL-NERVOUS-SYSTEM DETECTED BY SPECIFIC MONOCLONAL-ANTIBODIES [J].

KOTANI, M ;

KAWASHIMA, I ;

OZAWA, H ;

TERASHIMA, T ;

TAI, T .

GLYCOBIOLOGY, 1993, 3 (02) :137-146

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