Efficient One-Pot Synthesis of Spirooxindole Derivatives Containing 1,4-Dihydropyridine-Fused-1,3-Diazaheterocycle Fragments via Four-Component Reaction

被引：30

作者：

Alizadeh, Abdolali ^{[1
]}

Firuzyar, Tahereh ^{[1
]}

Mikaeili, Azadeh ^{[1
]}

机构：

[1] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

来源：

SYNTHESIS-STUTTGART | 2010年 / 22期

关键词：

spirooxindole; 1,4-dihydropyridine; malononitrile; 1; n-diamine; 1,1-bis(methylthio)-2-nitroethylene; multicomponent reaction; DIASTEREOSELECTIVE SYNTHESIS; MULTICOMPONENT REACTIONS; 1,4-DIHYDROPYRIDINES; CHEMISTRY; INHIBITORS; DESIGN; ROUTE;

D O I：

10.1055/s-0030-1258249

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

An efficient, one-pot synthetic protocol toward spirooxindole derivatives containing 1,4-dihydropyridine-fused 1,3-diaza-heterocycle fragments, a class of biologically active compounds starting from 1,1-bis(methylthio)-2-nitroethylene, 1, n-diamine, isatin, or its derivatives, and malononitrile is described. The reaction proceeds in ethanol in the presence of 10 mol% of piperidine as a basic catalyst under reflux conditions to produce the title compounds in 74-85% yields.

引用

页码：3913 / 3917

页数：5

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[2]

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[3]

A novel pseudo-seven-component diastereoselective synthesis of λ5-phosphanylidene bis(2,5-dioxotetrahydro-1H-pyrrole-3-carboxylates) via binucleophilic systems [J].