Corticotropin-releasing hormone (CRH) receptors in the mesenteric small arteries of rats resemble the (2)-subtype

被引：34

作者：

Rohde, E

Furkert, J

Fechner, K

Beyermann, M

Mulvany, MJ

Richter, RM

Denef, C

Bienert, M

Berger, H

机构：

[1] RES INST MOL PHARMACOL, D-10315 BERLIN, GERMANY

[2] AARHUS UNIV, DEPT PHARMACOL, DK-8000 AARHUS C, DENMARK

[3] CATHOLIC UNIV LEUVEN, SCH MED, LAB CELL PHARMACOL, B-3000 LOUVAIN, BELGIUM

来源：

BIOCHEMICAL PHARMACOLOGY | 1996年 / 52卷 / 06期

关键词：

CRH agonists; CRH antagonist; rat; receptor; arteries; pituitary;

D O I：

10.1016/0006-2952(96)00300-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The potencies of the corticotropin-releasing hormone (CRH) agonistic peptides oCRH, h/rCRH, frog sauvagine, and carp urotensin I and of the antagonistic peptide alpha-helical CRH9-41 were compared in 3 different in vitro assays: (a) receptor binding to rat brain membranes; (b) release of ACTH/beta-endorphin from rat pituitary cells; and (c) relaxation of rat mesenteric small arteries. From their potency profiles, especially from the high potency of sauvagine relative to CRH in the relaxation assay, it is concluded that the receptors mediating the hypotensive action of systemic CRH in Vascular smooth muscle are different from those in the pituitary and brain, and may be identical or very similar to the recently cloned new CRH receptor type 2.

引用

页码：829 / 833

页数：5