Neuroproteomics: understanding the molecular organization and complexity of the brain

被引：132

作者：

Bayes, Alex ^{[1
]}

Grant, Seth G. N. ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England

来源：

NATURE REVIEWS NEUROSCIENCE | 2009年 / 10卷 / 09期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

2-DIMENSIONAL GEL-ELECTROPHORESIS; DIFFERENTIAL PROTEIN EXPRESSION; CEREBROSPINAL-FLUID PROTEINS; UBIQUITIN-PROTEASOME SYSTEM; ANTERIOR CINGULATE CORTEX; CODED AFFINITY TAGS; PROTEOMIC ANALYSIS; MASS-SPECTROMETRY; MOUSE-BRAIN; POSTSYNAPTIC DENSITY;

D O I：

10.1038/nrn2701

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Advances in technology have equipped the field of neuroproteomics with refined tools for the study of the expression, interaction and function of proteins in the nervous system. In combination with bioinformatics, neuroproteomics can address the organization of dynamic, functional protein networks and macromolecular structures that underlie physiological, anatomical and behavioural processes. Furthermore, neuroproteomics is contributing to the elucidation of disease mechanisms and is a powerful tool for the identification of biomarkers.

引用

页码：635 / 646

页数：12

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