Dosage compensation: the beginning and end of generalization

被引：174

作者：

Straub, Tobias ^{[1
]}

Becker, Peter B. ^{[1
]}

机构：

[1] Univ Munich, Dept Mol Biol, Adolf Butenandt Inst, D-80336 Munich, Germany

来源：

NATURE REVIEWS GENETICS | 2007年 / 8卷 / 01期

关键词：

D O I：

10.1038/nrg2013

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genomes of higher eukaryotes are carefully balanced systems of gene expression that compensate for the different numbers of sex chromosomes in the two sexes by adjusting gene expression levels. Different strategies for sex chromosome dosage compensation have evolved, which all involve modulating chromatin structure as a means to fine-tune transcription levels. As data accumulate, previous over-simplifications are being revised, and novel features of the compensation processes are gaining attention, many of which are of sufficient global validity to influence our view on gene expression beyond the realm of dosage compensation itself.

引用

页码：47 / 57

页数：11

共 82 条

[1] Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila [J].

Akhtar, A ;

Becker, PB .

MOLECULAR CELL, 2000, 5 (02) :367-375

[2] High-resolution ChIP-chip analysis reveals that the Drosophila MSL complex selectively identifies active genes on the male X chromosome [J].

Alekseyenko, AA ;

Larschan, E ;

Lai, WR ;

Park, PJ ;

Kuroda, MI .

GENES & DEVELOPMENT, 2006, 20 (07) :848-857

[3] Biological functions of the ISWI chromatin remodeling complex NURF [J].

Badenhorst, P ;

Voas, M ;

Rebay, I ;

Wu, C .

GENES & DEVELOPMENT, 2002, 16 (24) :3186-3198

[4] Sequence-specific targeting of MSL complex regulates transcription of the roX RNA genes [J].

Bai, XY ;

Alekseyenko, AA ;

Kuroda, MI .

EMBO JOURNAL, 2004, 23 (14) :2853-2861

[5] X-chromosome targeting and dosage compensation are mediated by distinct domains in MSL-3 [J].

Buscaino, A ;

Legube, G ;

Akhtar, A .

EMBO REPORTS, 2006, 7 (05) :531-538

[6] MOF-Regulated acetylation of MSL-3 in the Drosophila dosage compensation complex [J].

Buscaino, A ;

Köcher, T ;

Kind, JH ;

Holz, H ;

Taipale, M ;

Wagner, K ;

Wilm, M ;

Akhtar, A .

MOLECULAR CELL, 2003, 11 (05) :1265-1277

[7] SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope [J].

Cabal, Ghislain G. ;

Genovesio, Auguste ;

Rodriguez-Navarro, Susana ;

Zimmer, Christophe ;

Gadal, Olivier ;

Lesne, Annick ;

Buc, Henri ;

Feuerbach-Fournier, Frank ;

Olivo-Marin, Jean-Christophe ;

Hurt, Eduard C. ;

Nehrbass, Ulf .

NATURE, 2006, 441 (7094) :770-773

[8] X-inactivation profile reveals extensive variability in X-linked gene expression in females [J].

Carrel, L ;

Willard, HF .

NATURE, 2005, 434 (7031) :400-404

[9] Chromatin of the Barr body: histone and non-histone proteins associated with or excluded from the inactive X chromosome [J].

Chadwick, BP ;

Willard, HF .

HUMAN MOLECULAR GENETICS, 2003, 12 (17) :2167-2178

[10] The evolution of chromosomal sex determination and dosage compensation [J].

Charlesworth, B .

CURRENT BIOLOGY, 1996, 6 (02) :149-162

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