Stability of amorphous indomethacin compounded with silica

被引：115

作者：

Watanabe, T

Wakiyama, N

Usui, F

Ikeda, M

Isobe, T

Senna, M

机构：

[1] Sankyo Co Ltd, Prod Dev Labs, Shinagawa Ku, Tokyo 1408710, Japan

[2] Keio Univ, Fac Sci & Technol, Yokohama, Kanagawa 2238522, Japan

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2001年 / 226卷 / 1-2期

关键词：

crystallization; solid-state NMR; indomethacin; co-ground mixture; interaction;

D O I：

10.1016/S0378-5173(01)00776-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The stability of indomethacin (IM) compounded with SiO2 either by co-grinding or by melt-quenching was examined by recrystallization kinetics under the conditions 30 degreesC and 11% relative humidity. A decrease of the recrystallization rate with and without an appreciable induction period was observed in both compounds. Higher stability of amorphous IM compounded with SiO2 was attained by prolonged co-grinding than by melt-quenching. This was explained by the stronger chemical interaction at the interface between IM and SiO2 by co-grinding, as revealed by Si-29 and C-13 solid state NMR. Incomplete co-grinding with the rest of the crystalline state, however, made the amorphous state appreciably unstable, since the remaining crystallites serve as seeds for recrystallization. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：81 / 91

页数：11