Antileishmanial activity of azithromycin against Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis, and Leishmania (Leishmania) chagasi

被引：29

作者：

de Oliveira-Silva, Fernanda ^{[1
]}

de Morais-Teixeira, Eliane ^{[1
]}

Rabello, Ana ^{[1
]}

机构：

[1] Fdn Oswaldo Cruz Fiocruz, Inst Rene Rachou, Lab Clin Res, BR-30190002 Belo Horizonte, MG, Brazil

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2008年 / 78卷 / 05期

关键词：

D O I：

10.4269/ajtmh.2008.78.745

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 [公共卫生与预防医学]; 120402 [社会医学与卫生事业管理];

摘要：

Azithromycin, an azalide antibiotic, is highly concentrated within different phagocytic cells, especially macrophages. The potential antileishmanial activity of azithromycin against three species of Leishmania from the New World was assessed using in vitro models. Azithromycin decreased viability of promastigote cultures of Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis, and Leishmania (Leishmania) chagasi as determined by the colorimetric Alamar blue assay. In amastigote intracellular cultures, a significant decrease in infected macrophages counts was observed for all three species with IC50 of 20.83 (27 mu mol/L), 2.18 (2.7 mu mol/L), and 6.12 (7.8 mu mol/L) mu g/mL, respectively. Azithromycin showed in vitro activity against L. (L.) amazonensis, L. (V.) braziliensis, and L. (L.) chagasi and may offer an alternative to current leishmaniasis treatment.

引用

页码：745 / 749

页数：5

共 29 条

[1]

THE USE OF ITRACONAZOLE IN THE TREATMENT OF LEISHMANIASIS CAUSED BY LEISHMANIA-AETHIOPICA [J].