Inherited thrombophilia and pregnancy loss

被引：19

作者：

Brenner, B ^{[1
]}

机构：

[1] Rambam Med Ctr, Dept Haematol, Thrombosis & Haemostasis Unit, IL-31096 Haifa, Israel

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2003年 / 16卷 / 02期

关键词：

fetal loss; thrombophilia; low-molecular-weight heparin; placenta; thrombosis;

D O I：

10.1016/S1521-6926(02)00097-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A growing body of evidence obtained during the past 6 years suggests a significant role for inherited thrombophilia in the development of gestational vascular complications. Case-control and cross-sectional studies have demonstrated that thrombophilia is more prevalent in cohorts of women with pregnancy loss. Placental pathological findings in women with thrombophilia are hallmarked by thrombosis and fibrin deposition. Preliminary case-control studies suggest that low-molecular-weight heparins (LMWH) are effective in preventing pregnancy loss in women with thrombophilia and previous fetal wastage.

引用

页码：311 / 320

页数：10

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