AMPK: a nutrient and energy sensor that maintains energy homeostasis

被引：3504

作者：

Hardie, D. Grahame ^{[1
]}

Ross, Fiona A. ^{[1
]}

Hawley, Simon A. ^{[1
]}

机构：

[1] Univ Dundee, Div Cell Signalling & Immunol, Coll Life Sci, Dundee DD1 5EH, Scotland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2012年 / 13卷 / 04期

基金：

英国惠康基金;

关键词：

ACTIVATED PROTEIN-KINASE; ACETYL-COA CARBOXYLASE; FATTY-ACID OXIDATION; GLUCOSE-UPTAKE; DIETARY RESTRICTION; SKELETAL-MUSCLE; DIRECT PHOSPHORYLATION; STRUCTURAL INSIGHT; UPSTREAM KINASE; 14-3-3; BINDING;

D O I：

10.1038/nrm3311

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by falling energy status, it promotes ATP production by increasing the activity or expression of proteins involved in catabolism while conserving ATP by switching off biosynthetic pathways. AMPK also regulates metabolic energy balance at the whole-body level. For example, it mediates the effects of agents acting on the hypothalamus that promote feeding and entrains circadian rhythms of metabolism and feeding behaviour. Finally, recent studies reveal that AMPK conserves ATP levels through the regulation of processes other than metabolism, such as the cell cycle and neuronal membrane excitability.

引用

页码：251 / 262

页数：12

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