AMPK: a nutrient and energy sensor that maintains energy homeostasis

被引：3504

作者：

Hardie, D. Grahame ^{[1
]}

Ross, Fiona A. ^{[1
]}

Hawley, Simon A. ^{[1
]}

机构：

[1] Univ Dundee, Div Cell Signalling & Immunol, Coll Life Sci, Dundee DD1 5EH, Scotland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2012年 / 13卷 / 04期

基金：

英国惠康基金;

关键词：

ACTIVATED PROTEIN-KINASE; ACETYL-COA CARBOXYLASE; FATTY-ACID OXIDATION; GLUCOSE-UPTAKE; DIETARY RESTRICTION; SKELETAL-MUSCLE; DIRECT PHOSPHORYLATION; STRUCTURAL INSIGHT; UPSTREAM KINASE; 14-3-3; BINDING;

D O I：

10.1038/nrm3311

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by falling energy status, it promotes ATP production by increasing the activity or expression of proteins involved in catabolism while conserving ATP by switching off biosynthetic pathways. AMPK also regulates metabolic energy balance at the whole-body level. For example, it mediates the effects of agents acting on the hypothalamus that promote feeding and entrains circadian rhythms of metabolism and feeding behaviour. Finally, recent studies reveal that AMPK conserves ATP levels through the regulation of processes other than metabolism, such as the cell cycle and neuronal membrane excitability.

引用

页码：251 / 262

页数：12

共 121 条

[11] Resveratrol improves health and survival of mice on a high-calorie diet [J].

Baur, Joseph A. ;

Pearson, Kevin J. ;

Price, Nathan L. ;

Jamieson, Hamish A. ;

Lerin, Carles ;

Kalra, Avash ;

Prabhu, Vinayakumar V. ;

Allard, Joanne S. ;

Lopez-Lluch, Guillermo ;

Lewis, Kaitlyn ;

Pistell, Paul J. ;

Poosala, Suresh ;

Becker, Kevin G. ;

Boss, Olivier ;

Gwinn, Dana ;

Wang, Mingyi ;

Ramaswamy, Sharan ;

Fishbein, Kenneth W. ;

Spencer, Richard G. ;

Lakatta, Edward G. ;

Le Couteur, David ;

Shaw, Reuben J. ;

Navas, Placido ;

Puigserver, Pere ;

Ingram, Donald K. ;

de Cabo, Rafael ;

Sinclair, David A. .

NATURE, 2006, 444 (7117) :337-342

[12] Network organization of the human autophagy system [J].

Behrends, Christian ;

Sowa, Mathew E. ;

Gygi, Steven P. ;

Harper, J. Wade .

NATURE, 2010, 466 (7302) :68-U84

[13] Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle [J].

Canto, Carles ;

Jiang, Lake Q. ;

Deshmukh, Atul S. ;

Mataki, Chikage ;

Coste, Agnes ;

Lagouge, Marie ;

Zierath, Juleen R. ;

Auwerx, Johan .

CELL METABOLISM, 2010, 11 (03) :213-219

[14] Subunit and Domain Requirements for Adenylate-mediated Protection of Snf1 Kinase Activation Loop from Dephosphorylation [J].

Chandrashekarappa, Dakshayini G. ;

McCartney, Rhonda R. ;

Schmidt, Martin C. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (52) :44532-44541

[15] Structural insight into the autoinhibition mechanism of AMP-activated protein kinase [J].

Chen, Lei ;

Jiao, Zhi-Hao ;

Zheng, Li-Sha ;

Zhang, Yuan-Yuan ;

Xie, Shu-Tao ;

Wang, Zhi-Xin ;

Wu, Jia-Wei .

NATURE, 2009, 459 (7250) :1146-U139

[16] Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators [J].

Chen, Shuai ;

Murphy, Jane ;

Toth, Rachel ;

Campbell, David G. ;

Morrice, Nick A. ;

Mackintosh, Carol .

BIOCHEMICAL JOURNAL, 2008, 409 :449-459

[17] Mice with AS160/TBC1D4-Thr649Ala Knockin Mutation Are Glucose Intolerant with Reduced Insulin Sensitivity and Altered GLUT4 Trafficking [J].

Chen, Shuai ;

Wasserman, David H. ;

MacKintosh, Carol ;

Sakamoto, Kei .

CELL METABOLISM, 2011, 13 (01) :68-79

[18] AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons [J].

Claret, Marc ;

Smith, Mark A. ;

Batterham, Rachel L. ;

Selman, Colin ;

Choudhury, Agharul I. ;

Fryer, Lee G. D. ;

Clements, Melanie ;

Al-Qassab, Hind ;

Heffron, Helen ;

Xu, Allison W. ;

Speakman, John R. ;

Barsh, Gregory S. ;

Viollet, Benoit ;

Vaulont, Sophie ;

Ashford, Michael L. J. ;

Carling, David ;

Withers, Dominic J. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (08) :2325-2336

[19] REGULATION OF HMG-COA REDUCTASE - IDENTIFICATION OF THE SITE PHOSPHORYLATED BY THE AMP-ACTIVATED PROTEIN-KINASE INVITRO AND IN INTACT RAT-LIVER [J].

CLARKE, PR ;

HARDIE, DG .

EMBO JOURNAL, 1990, 9 (08) :2439-2446

[20] ROLE OF THE AMP-ACTIVATED PROTEIN-KINASE IN THE CELLULAR STRESS-RESPONSE [J].

CORTON, JM ;

GILLESPIE, JG ;

HARDIE, DG .

CURRENT BIOLOGY, 1994, 4 (04) :315-324

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