A novel method for measuring the bending rigidity of model lipid membranes by simulating tethers

被引：111

作者：

Harmandaris, Vagelis A. ^{[1
]}

Deserno, Markus ^{[1
]}

机构：

[1] Max Planck Inst Polymer Res, D-55128 Mainz, Germany

来源：

JOURNAL OF CHEMICAL PHYSICS | 2006年 / 125卷 / 20期

关键词：

MOLECULAR-DYNAMICS SIMULATIONS; FLUID BILAYER-MEMBRANES; THERMAL FLUCTUATIONS; MECHANICAL-PROPERTIES; ELASTICITY; VESICLES; UNDULATIONS; DEFORMATIONS; TENSION;

D O I：

10.1063/1.2372761

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The tensile force along a cylindrical lipid bilayer tube is proportional to the membrane's bending modulus and inversely proportional to the tube radius. We show that this relation, which is experimentally exploited to measure bending rigidities, can be applied with even greater ease in computer simulations. Using a coarse-grained bilayer model we efficiently obtain bending rigidities that compare very well with complementary measurements based on an analysis of thermal undulation modes. We furthermore illustrate that no deviations from simple quadratic continuum theory occur up to a radius of curvature comparable to the bilayer thickness. (c) 2006 American Institute of Physics.

引用

页数：6

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