Dibenzoyldiazomethane-acridine conjugate: A novel DNA photofootprinting agent

被引：12

作者：

Nakatani, K

Shirai, J

Sando, S

Saito, I

机构：

[1] Department of Synthetic Chemistry, Faculty of Engineering, Kyoto University

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(97)01357-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dibenzoyldiazomethane derivative covalently attached to acridine effectively cleaves DNA by photoirradiation with long wavelength UV light (> 400 nm). DNA cleavage experiments using P-32-5'-end-labeled DNA showed that the cleavage by the conjugate is neither sequence nor base selective, indicating that DBDM-acridine conjugate can be used as a photofootprinting agent. (C) 1997 Elsevier Science Ltd.

引用

页码：6047 / 6050

页数：4