Rho GTPase Effector Functions in Tumor Cell Invasion and Metastasis

被引：29

作者：

Baranwal, Somesh ^{[1
]}

Alahari, Suresh K. ^{[1
,2
]}

机构：

[1] LSU Sch Med, Dept Biochem & Mol Biol, New Orleans, LA 70112 USA

[2] LSU Sch Med, Stanley Scott Canc Ctr, New Orleans, LA 70112 USA

来源：

CURRENT DRUG TARGETS | 2011年 / 12卷 / 08期

关键词：

Rho GTPase; ROCK; PAK; IQGAP; oncogenesis; BREAST-CANCER CELLS; MITOGEN-INDUCIBLE GENE-6; PHOSPHOLIPASE-D; EPITHELIAL-CELLS; HEPATOCELLULAR-CARCINOMA; TYROSINE KINASE; E-CADHERIN; PLASMINOGEN-ACTIVATOR; P21-ACTIVATED KINASES; ALTERED EXPRESSION;

D O I：

10.2174/138945011795906534

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rho GTPases (Ras homologous family) comprise the largest subfamily cluster of the Ras-homology superfamily. Rho GTPases exist in inactive GDP and active GTP forms. The active forms of the Rho family members bind with numerous effector proteins that are crucial for various biological processes. Accumulating evidence exemplifies the importance of Rho effector proteins in various steps of cancer progression. Here, we highlight the actions of various effectors of Rho members in cancer invasion and metastasis.

引用

页码：1194 / 1201

页数：8

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