Clinical uses and misuses of dehydroepiandrosterone

被引：22

作者：

Binello, E

Gordon, CM

机构：

[1] Childrens Hosp, Dept Endocrinol, Boston, MA 02115 USA

[2] MIT, Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[3] Childrens Hosp, Dept Adolescent Med, Boston, MA 02115 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2003年 / 3卷 / 06期

关键词：

D O I：

10.1016/j.coph.2003.07.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dehydroepiandrosterone is the most abundant adrenal androgen and also functions as a neurosteroid. Serum concentrations decline with age and can serve as a prognostic factor in both critical illnesses and breast cancer progression. Evidence is accruing in support of dehydroepiandrosterone supplementation in adrenal insufficiency, hypopituitarism, osteoporosis, systemic lupus erythematosus, depression and schizophrenia. Research is ongoing at both the basic and the clinical level to elucidate mechanisms of action and establish efficacy and safety, as well as to expand new areas of potential application for this multi-faceted hormone.

引用

收藏

页码：635 / 641

页数：7

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