Transforming growth factor β, pleiotropic regulator of hematopoietic stem cells:: Potential physiological and clinical relevance

被引：26

作者：

Ruscetti, FW

Bartelmez, SH

机构：

[1] NCI, Frederick Canc Res & Dev Ctr, Leukocyte Biol Sect, Basic Res Lab,Ctr Canc Res, Frederick, MD 21702 USA

[2] Univ Washington, Sch Publ Hlth, Dept Pathobiol, Seattle, WA 98195 USA

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2001年 / 74卷 / 01期

关键词：

transforming growth factor-beta 1; hematopoiesis; autocrine; paracrine; stem cells;

D O I：

10.1007/BF02982545

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Transforming growth factor beta (TGF-beta) is a pleiotropic regulator of all stages of hematopoieis. Depending on the differentiation stage of the target cell, the local environment, and the concentration of TGF-beta, TGF-beta can be proproliferative or antiproliferative, proapoptotic or antiapoptotic, and/or prodifferentiative or antidifferentiative. TGF-beta is the major regulator of stem cell quiescence and can act directly or indirectly through effects on the marrow microenvironment. In addition, paracrine and autocrine actions of TGF-beta have overlapping but distinct regulatory effects on hematopoietic stem/progenitor cells. Neutralization of autocrine TGF-beta has therapeutic potential. (C) 2001 The Japanese Society of Hematology.

引用

页码：18 / 25

页数：8

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