Anti-interleukin-5 therapy for asthma and hypereosinophilic syndrome

被引：28

作者：

Kay, AB

Klion, AD

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Allergy & Clin Immunol, London SW3 6LY, England

[2] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2004年 / 24卷 / 04期

关键词：

D O I：

10.1016/j.iac.2004.06.007

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Interleukin 5 (IL-5) is a key cytokine in the regulation of eosinophiha and eosinophil activation in humans. Monoclonal antibodies to anti-IL-5 have become available for use in clinical studies in humans. This article discusses the rationale for the use of anti-IL-5 therapy in asthma and hypereosinophilic syndrome and summarizes the available clinical data on the use of anti-IL-5 to treat these disorders.

引用

页码：645 / +

页数：23

共 102 条

[1] ADHESION TO FIBRONECTIN PROLONGS EOSINOPHIL SURVIVAL [J].

ANWAR, ARF ;

MOQBEL, R ;

WALSH, GM ;

KAY, AB ;

WARDLAW, AJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (03) :839-843

[2]

Aractingi S, 1996, ARCH DERMATOL, V132, P535

[3]

Assa'ad AH, 2000, CHEM IMMUNOL, V76, P208

[4] Prednisolone treatment in asthma - Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa [J].

Bentley, AM ;

Hamid, Q ;

Robinson, DS ;

Schotman, E ;

Meng, Q ;

Assoufi, B ;

Kay, AB ;

Durham, SR .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 153 (02) :551-556

[5] Airway subepithelial fibrosis in a murine model of atopic asthma - Suppression by dexamethasone or anti-interleukin-5 antibody [J].

Blyth, DI ;

Wharton, TF ;

Pedrick, MS ;

Savage, TJ ;

Sanjar, S .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2000, 23 (02) :241-246

[6] RESPONSE OF 6 PATIENTS WITH IDIOPATHIC-HYPEREOSINOPHILIC-SYNDROME TO INTERFERON-ALFA [J].

BUTTERFIELD, JH ;

GLEICH, GJ .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1994, 94 (06) :1318-1326

[7] Monoclonal anti-interleukin-5 treatment suppresses eosinophil but not T-cell functions [J].

Büttner, C ;

Lun, A ;

Splettstoesser, T ;

Kunkel, G ;

Renz, H .

EUROPEAN RESPIRATORY JOURNAL, 2003, 21 (05) :799-803

[8] Airways remodeling is a distinctive feature of asthma and is related to severity of disease [J].

Chetta, A ;

Foresi, A ;

DelDonno, M ;

Bertorelli, G ;

Pesci, A ;

Olivieri, D .

CHEST, 1997, 111 (04) :852-857

[9] Inhibition of airway remodeling in IL-5-deficient mice [J].

Cho, JY ;

Miller, M ;

Baek, KJ ;

Han, JW ;

Nayar, J ;

Lee, SY ;

McElwain, K ;

McElwain, S ;

Friedman, S ;

Broide, DH .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (04) :551-560

[10] HYPEREOSINOPHILIC SYNDROME - ANALYSIS OF 14 CASES WITH REVIEW OF LITERATURE [J].

CHUSID, MJ ;

DALE, DC ;

WEST, BC ;

WOLFF, SM .

MEDICINE, 1975, 54 (01) :1-27

← 1 2 3 4 5 6 7 8 9 10 →