Modulation of osteoclast formation

被引：83

作者：

Quinn, JMW ^{[1
]}

Gillespie, MT ^{[1
]}

机构：

[1] St Vincents Inst Med Res, Fitzroy, Vic 3065, Australia

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 328卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.bbrc.2004.11.076

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Osteoclasts are derived following the fusion of precursors of hematopoietic and myelomonocytic origin after appropriate stimulus, such as that afforded by RANKL and M-CSF. Thus the osteoclast can be considered as a specialized type of macrophage, and several of the factors that affect osteoclast formation also have affects upon macrophage differentiation. Inhibitors of osteoclast formation may perturb RANKL or M-CSF signalling or affect other signalling pathways. Several of these inhibitors are discussed with the view of their capacity to influence osteoclast differentiation, but not necessarily their activity. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：739 / 745

页数：7

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