Combinatorial libraries -: from solution to 2D microarrays

被引：36

作者：

Díaz-Mochón, JJ ^{[1
]}

Bialy, L ^{[1
]}

Keinicke, L ^{[1
]}

Bradley, M ^{[1
]}

机构：

[1] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 11期

关键词：

D O I：

10.1039/b415847d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enzymatic modifications of split and mix libraries were followed by "pulling down" onto a 2-dimensional DNA microarray, via PNA tagging; this allowed complete library interrogation of all members of the split and mix library.

引用

页码：1384 / 1386

页数：3

共 20 条

[1]

Arya P, 2001, ANGEW CHEM INT EDIT, V40, P339, DOI 10.1002/1521-3773(20010119)40:2<339::AID-ANIE339>3.0.CO

[2]

2-J

[3] ENCODED COMBINATORIAL CHEMISTRY [J].

BRENNER, S ;

LERNER, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (12) :5381-5383

[4] Synthesis of a PNA-encoded cysteine protease inhibitor library [J].

Debaene, F ;

Mejias, L ;

Harris, JL ;

Winssinger, N .

TETRAHEDRON, 2004, 60 (39) :8677-8690

[5] Full orthogonality between Dde and Fmoc:: The direct synthesis of PNA-peptide conjugates [J].

Díaz-Mochón, JJ ;

Bialy, L ;

Bradley, M .

ORGANIC LETTERS, 2004, 6 (07) :1127-1129

[6]

Furka A, 2002, DRUG DISCOV TODAY, V7, P1

[7] Combinatorial solid-state chemistry of inorganic materials [J].

Koinuma, H ;

Takeuchi, I .

NATURE MATERIALS, 2004, 3 (07) :429-438

[8] Synthesis of protein-nucleic acid conjugates by expressed protein ligation [J].

Lovrinovic, M ;

Seidel, R ;

Wacker, R ;

Schroeder, H ;

Seitz, O ;

Engelhard, M ;

Goody, RS ;

Niemeyer, CM .

CHEMICAL COMMUNICATIONS, 2003, (07) :822-823

[9] A GENERAL-METHOD FOR MOLECULAR TAGGING OF ENCODED COMBINATORIAL CHEMISTRY LIBRARIES [J].

NESTLER, HP ;

BARTLETT, PA ;

STILL, WC .

JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (17) :4723-4724

[10] SEQUENCE-SELECTIVE RECOGNITION OF DNA BY STRAND DISPLACEMENT WITH A THYMINE-SUBSTITUTED POLYAMIDE [J].

NIELSEN, PE ;

EGHOLM, M ;

BERG, RH ;

BUCHARDT, O .

SCIENCE, 1991, 254 (5037) :1497-1500

← 1 2 →