Synthesis of a PNA-encoded cysteine protease inhibitor library

被引：43

作者：

Debaene, F

Mejias, L

Harris, JL

Winssinger, N

机构：

[1] Univ Strasbourg, Inst Sci & Ingn Supramol, F-67000 Strasbourg, France

[2] Novartis Res Fdn, Genomics Inst, Dept Chem, San Diego, CA 92121 USA

[3] Scripps Res Inst, Dept Biol Mol, La Jolla, CA 92037 USA

来源：

TETRAHEDRON | 2004年 / 60卷 / 39期

关键词：

microarrays; combinatorial chemistry; protease inhibitors; peptide nucleic acid;

D O I：

10.1016/j.tet.2004.05.107

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Peptide nucleic acids (PNAs) have been used to encode a combinatorial library whereby each compound is labeled with a PNA tag which reflects its synthetic history and localizes the compound upon hybridization to an oligonucleotide array. We report herein the full synthetic details for a 4000 member PNA-encoded library targeted towards cysteine protease. (C) 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：8677 / 8690

页数：14

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