A highly efficient three-component coupling of aldehyde, alkyne, and amines via C-H activation catalyzed by gold in water

被引：643

作者：

Wei, CM

Li, CJ ^{[1
]}

机构：

[1] Tulane Univ, Dept Chem, New Orleans, LA 70118 USA

[2] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 32期

关键词：

D O I：

10.1021/ja0359299

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient three-component-coupling of aldehyde, alkyne, and amine (A3 Coupling) catalyzed by gold via C-H activation was developed in water. The reaction is general, and nearly quantitative yields of the corresponding propargylamines were obtained in most cases. Both aromatic and aliphatic aldehydes and amines can be used for the reaction. No additional cocatalyst or activator is required. A mechanistic rationale for the reaction has been proposed. Copyright © 2003 American Chemical Society.

引用

页码：9584 / 9585

页数：2

共 46 条

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