Multiple solid-phase synthesis of hydantoins and thiohydantoins

被引：12

作者：

Bhalay, G ^{[1
]}

Cowell, D ^{[1
]}

Hone, ND ^{[1
]}

Scobie, M ^{[1
]}

Baxter, AD ^{[1
]}

机构：

[1] Oxford Asymmetry Ltd, Oxford Divers, Abingdon OX14 4RX, Oxon, England

来源：

MOLECULAR DIVERSITY | 1998年 / 3卷 / 03期

关键词：

hydantoin; isocyanate; isothiocyanate; thiohydantoin;

D O I：

10.1023/A:1009612923900

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel general protocol for the construction of hydantoins and thiohydantoins on a solid support has been developed. Using this novel methodology, the synthesis of a diverse 96-compound library has been achieved. Resin-bound dipeptides are cyclised via the formation of an intermediate isocyanate or isothiocyanate on resin as the key step in the strategy.

引用

页码：195 / 198

页数：4

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