Effect of C60(OH)18 on membranes of rat liver microsomes during photosensitization

被引：12

作者：

Kamat, JP

Devasagayam, TPA ^{[1
]}

Mohan, H

Chiang, LY

Mittal, JP

机构：

[1] Bhabha Atom Res Ctr, Div Cell Biol, Bombay 400085, Maharashtra, India

[2] Bhabha Atom Res Ctr, Chem Grp, Bombay 400085, Maharashtra, India

[3] Natl Taiwan Univ, Ctr Condensed Matter Sci, Taipei 10764, Taiwan

来源：

FULLERENE SCIENCE AND TECHNOLOGY | 1998年 / 6卷 / 04期

关键词：

D O I：

10.1080/10641229809350227

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We have examined the ability of a water-soluble derivative of fullerene C-60, C-60(OH)(18), to induce alterations in rat liver microsomes during photosensitization. When it was exposed to UV (330-370 nm), it induced significant membrane damage in terms of (i) lipid peroxidation as assayed by various products and (ii) damage to proteins as assessed by protein carbonyls and loss of the membrane-bound enzymes. The damage induced was both time and concentration-dependent and seems to be predominantly due to radicals and to a lesser extent singlet oxygen.

引用

页码：663 / 679

页数：17

共 21 条

[1] Comparison of immunological effects of Fullerene C-60 and raw soot from Fullerene production on alveolar macrophages and macrophage like cells in vitro [J].