Bacterial enzymatic resistance:: β-lactamases and aminoglycoside-modifying enzymes

被引：28

作者：

Bush, K

Miller, GH

机构：

[1] RW Johnson Pharmaceut Res Inst, Raritan, NJ 08869 USA

[2] Microcide Pharmaceut Inst, Sunnyvale, CA 94043 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 1998年 / 1卷 / 05期

关键词：

D O I：

10.1016/S1369-5274(98)80082-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Numerous novel beta-lactamases and aminoglycoside-modifying enzymes with altered substrate profiles continue to be identified. Plasmid-mediated transmission of many of these enzymes readily occurs due to inclusion of the encoding genes in mobile gene cassettes. Recent crystallographic determinations of the structures of metallo-beta-lactamases and aminoglycoside-modifying enzymes provide the opportunity for the rational design of inhibitors.

引用

收藏

页码：509 / 515

页数：7

相关论文

共 81 条

[1] Aminoglycoside 2'-N-acetyltransferase genes are universally present in mycobacteria: Characterization of the aac(2')-lc gene from Mycobacterium tuberculosis and the aac(2')-ld gene from Mycobacterium smegmatis [J].

Ainsa, JA ;

Perez, E ;

Pelicic, V ;

Berthet, FX ;

Gicquel, B ;

Martin, C .

MOLECULAR MICROBIOLOGY, 1997, 24 (02) :431-441

[2] Expression of the AsbA1, OXA-12, and AsbM1 beta-lactamases in Aeromonas jandaei AER 14 is coordinated by a two-component regulon [J].

Alksne, LE ;

Rasmussen, BA .

JOURNAL OF BACTERIOLOGY, 1997, 179 (06) :2006-2013

[3]

Amoroso AM, 1998, ANTIMICROB AGENTS CH, V42, P228

[4] A novel class C beta-lactamase (FOX-2) in Escherichia coli conferring resistance to cephamycins [J].

Bauernfeind, A ;

Wagner, S ;

Jungwirth, R ;

Schneider, I ;

Meyer, D .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (09) :2041-2046

[5] Characterization of an inhibitor-resistant TEM (IRT) beta-lactamase in a novel strain of Klebsiella pneumoniae [J].

Bermudes, H ;

Jude, F ;

Arpin, C ;

Quentin, C ;

Morand, A ;

Labia, R .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (01) :222-222

[6] A237T as a modulating mutation in naturally occurring extended-spectrum TEM-type β-lactamases [J].

Blázquez, J ;

Negri, MC ;

Morosini, MI ;

Gómez-Gómez, JM ;

Baquero, F .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (05) :1042-1044

[7] CTX-M-5, a novel cefotaxime-hydrolyzing β-lactamase from an outbreak of Salmonella typhimurium in Latvia [J].

Bradford, PA ;

Yang, YJ ;

Sahm, D ;

Grope, I ;

Gardovska, D ;

Storch, G .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (08) :1980-1984

[8] Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the loss of an outer membrane protein [J].

Bradford, PA ;

Urban, C ;

Mariano, N ;

Projan, SJ ;

Rahal, JJ ;

Bush, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (03) :563-569

[9] Inhibitor-resistant TEM (IRT) beta-lactamases with different substitutions at position 244 [J].

Bret, L ;

Chaibi, EB ;

ChanalClaris, C ;

Sirot, D ;

Labia, R ;

Sirot, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (11) :2547-2549

[10] A FUNCTIONAL CLASSIFICATION SCHEME FOR BETA-LACTAMASES AND ITS CORRELATION WITH MOLECULAR-STRUCTURE [J].

BUSH, K ;

JACOBY, GA ;

MEDEIROS, AA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (06) :1211-1233

← 1 2 3 4 5 6 7 8 9 →