Bacterial enzymatic resistance:: β-lactamases and aminoglycoside-modifying enzymes

被引：28

作者：

Bush, K

Miller, GH

机构：

[1] RW Johnson Pharmaceut Res Inst, Raritan, NJ 08869 USA

[2] Microcide Pharmaceut Inst, Sunnyvale, CA 94043 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 1998年 / 1卷 / 05期

关键词：

D O I：

10.1016/S1369-5274(98)80082-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Numerous novel beta-lactamases and aminoglycoside-modifying enzymes with altered substrate profiles continue to be identified. Plasmid-mediated transmission of many of these enzymes readily occurs due to inclusion of the encoding genes in mobile gene cassettes. Recent crystallographic determinations of the structures of metallo-beta-lactamases and aminoglycoside-modifying enzymes provide the opportunity for the rational design of inhibitors.

引用

页码：509 / 515

页数：7