Monoglycerides from the brown alga Sargassum sagamianum:: Isolation, synthesis, and biological activity

被引：38

作者：

Chang, Hyeun Wook ^{[2
]}

Jang, Kyoung Hwa ^{[1
,3
]}

Lee, Doohyun ^{[1
]}

Kang, Hee Ryong ^{[1
]}

Kim, Tae-Yoon ^{[4
]}

Lee, Bong Ho ^{[5
]}

Choi, Byoung Wook ^{[5
]}

Kim, Sanghee ^{[1
,3
]}

Shin, Jongheon ^{[1
,3
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Youngnam Univ, Coll Pharm, Gyeongsangbuk 712749, South Korea

[3] Seoul Natl Univ, Inst Nat Prod Res, Seoul 151742, South Korea

[4] Catholic Univ Korea, Dept Dermatol, Seoul 137040, South Korea

[5] Hanbat Natl Univ, Dept Biotechnol, Taejon 305719, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 12期

关键词：

polyunsaturated fatt acid-derived; monoglycerides; brown alga; 1-octadecatetraenoyl glycerol; synthesis; bioactivity; inhibition of phospholipase A2; inhibition of cyclooxygenase-2;

D O I：

10.1016/j.bmcl.2008.05.008

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Polyunsaturated fatty acid-derived monoglycerides were characterized from the marine brown alga Sargassum sagamianum, collected from Jeju Island, Korea. A new compound of this structural class was isolated and determined to be 1-octadecatetraenoyl glycerol, by combined spectroscopic methods. Based on the structures and bioactivity of these compounds, a series of monoglycerides were synthesized using glycerol and various fatty acids. Several compounds exhibited moderate to significant inhibition of phospholipase A(2) and cyclooxygenase-2. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3589 / 3592

页数：4

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