A new one step synthesis of maleimides by condensation of glyoxylate esters with acetamides

被引：68

作者：

Faul, MM ^{[1
]}

Winneroski, LL ^{[1
]}

Krumrich, CA ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Res Labs, Chem Proc Res & Dev Div, Indianapolis, IN 46285 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(98)02594-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bisphenyl, bisheteroaryl, indolylaryl and indolylcycloalkyl maleimides are prepared in one step and 67-99% yield by condensation of glyoxylate esters with acetamides using a 1.0 M solution of potassium tert-butoxide in THF. The mechanism of the reaction is discussed. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：1109 / 1112

页数：4

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