Tamoxifen - DNA adduct formation in human endometrium

被引:7
作者
Beland, FA
Marques, MM
da Costa, GG
Phillips, DH
机构
[1] Natl Ctr Toxicol Res, Div Biochem Toxicol, Jefferson, AR 72079 USA
[2] Univ Tecn Lisboa, Ctr Quim Estrutural Complexo 1, Inst Super Tecn, P-1049001 Lisbon, Portugal
[3] Inst Canc Res, Sutton SM2 5NG, Surrey, England
关键词
D O I
10.1021/tx050255w
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1507 / 1509
页数:3
相关论文
共 12 条
[1]   Analysis of tamoxifen-DNA adducts in endometrial explants by MS and 32P-postlabeling [J].
Beland, FA ;
Churchwell, MI ;
Hewer, A ;
Phillips, DH ;
da Costa, GG ;
Marques, MM .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 320 (02) :297-302
[2]  
Carmichael PL, 1996, CANCER RES, V56, P1475
[3]   The metabolic activation of tamoxifen and α-hydroxytamoxifen to DNA-binding species in rat hepatocytes proceeds via sulphation [J].
Davis, W ;
Venitt, S ;
Phillips, DH .
CARCINOGENESIS, 1998, 19 (05) :861-866
[4]  
Divi RL, 1999, CANCER RES, V59, P4829
[5]   Formation of tamoxifen-DNA adducts in human endometrial explants exposed to α-hydroxytamoxifen [J].
Kim, SY ;
Suzuki, N ;
Laxmi, YRS ;
McGarrigle, BP ;
Olson, JR ;
Sharma, M ;
Sharma, M ;
Shibutani, S .
CHEMICAL RESEARCH IN TOXICOLOGY, 2005, 18 (05) :889-895
[6]  
Osborne MR, 1996, CANCER RES, V56, P66
[7]   Organ specificity of DNA adduct formation by tamoxifen and α-hydroxytamoxifen in the rat:: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment [J].
Phillips, DH ;
Hewer, A ;
Osborne, MR ;
Cole, KJ ;
Churchill, C ;
Arlt, VM .
MUTAGENESIS, 2005, 20 (04) :297-303
[8]  
POON GK, 1995, DRUG METAB DISPOS, V23, P377
[9]   Hepatic DNA adduct dosimetry in rats fed tamoxifen: a comparison of methods [J].
Schild, LJ ;
Phillips, DH ;
Osborne, MR ;
Hewer, A ;
Beland, FA ;
Churchwell, MI ;
Brown, K ;
Gaskell, M ;
Wright, E ;
Poirier, MC .
MUTAGENESIS, 2005, 20 (02) :115-124
[10]  
Schild LJ, 2003, CANCER RES, V63, P5999