Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-δ accelerates intestinal adenoma growth

被引：247

作者：

Gupta, RA

Wang, DZ

Katkuri, S

Wang, HB

Dey, SK

DuBois, RN ^{[1
]}

机构：

[1] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Dept Med, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Dept Pediat & Cell & Dev Biol, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Dept Canc Biol, Nashville, TN 37232 USA

来源：

NATURE MEDICINE | 2004年 / 10卷 / 03期

关键词：

D O I：

10.1038/nm993

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We treated Apc(min) mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-delta0 (PPAR-delta). Exposure of Apc(min) mice to the PPAR-ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-delta activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-delta in the regulation of intestinal adenoma growth.

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页码：245 / 247

页数：4

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