bcl-2 alters influenza virus yield, spread, and hemagglutinin glycosylation

被引：100

作者：

Olsen, CW

Kehren, JC

DybdahlSissoko, NR

Hinshaw, VS

机构：

来源：

JOURNAL OF VIROLOGY | 1996年 / 70卷 / 01期

关键词：

D O I：

10.1128/JVI.70.1.663-666.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We previously demonstrated that expression of bcl-2 in Madin-Darby canine kidney (MDCK cells blocks influenza virus-induced apoptosis and DNA fragmentation. We show here that expression of bcl-2 also reduces the level of infectious virus production and the spread of virus in MDCK cell cultures infected at a low multiplicity of infection. This effect is associated with modified glycosylation of the hemagglutinin protein.

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页码：663 / 666

页数：4

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