Synthesis of polyelectrolytes bearing phosphorylcholine Moieties

被引：10

作者：

Reisch, Andreas ^{[1
]}

Voegel, Jean-Claude ^{[2
]}

Decher, Gero ^{[1
]}

Schaaf, Pierre ^{[1
]}

Mesini, Philippe J. ^{[1
]}

机构：

[1] Inst Charles Sadron, F-67083 Strasbourg, France

[2] Fac Chirurg Dent, INSERM, U595, F-67085 Strasbourg, France

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2007年 / 28卷 / 23期

关键词：

biomimetic; modification; phosphorylcholine; polyelectroytes; poly(L-glutamic acid); poly(L-lySine); TRANSFER RADICAL POLYMERIZATION; PHOSPHOLIPID POLAR GROUP; IN-SITU POLYMERIZATION; BY-LAYER DEPOSITION; PROTEIN ADSORPTION; CYTOMIMETIC BIOMATERIALS; GLUTAMIC ACID; SURFACE; MULTILAYER; POLYMERS;

D O I：

10.1002/marc.200700510

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We report on the modification of the polyelectrolytes Poly(L-glutamic acid) (PGA), poly(acrylic acid) (PAA), and Poly(L-lySine) (PLL) with side groups bearing phosphorylcholine (PC) groups. Two different side chains were synthesized from monoamino tri- or tetraethylene glycol, both with PC group linked to the OH end: the tert-butyloxycarbonyl protected compounds BOCNH(EO)(n)PC (n = 2, 3) and the succinylated compound SucNH(EO)(3)PC. BOCNH(EO)(n)PC was deprotected and the resulting amine was con- X Y densed with PGA or PAA and SucNH(EO)3PC was directly coupled to PLL. Degrees of substitution as high as 80% were obtained with the method described. These polyelectrolytes are potential candidates to fabricate multilayers with protein repellent properties.

引用

页码：2217 / 2223

页数：7

共 43 条

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