Stereospecific synthesis of EET metabolites via Suzuki-Miyaura coupling

被引：27

作者：

Falck, JR ^{[1
]}

Kumar, PS

Reddy, YK

Zou, G

Capdevila, JH

机构：

[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75390 USA

[3] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37232 USA

[4] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 41期

基金：

美国国家卫生研究院;

关键词：

eicosanoids; biologically active compounds; lipids; silver; Suzuki-Miyaura;

D O I：

10.1016/S0040-4039(01)01535-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bioactive, chain-shortened EET metabolites, viz. 8,9-epoxytetradec-5(Z)-enoic acid and 9,10-epoxyoctadec-6(Z), 12(Z)-dienoic acid, were prepared via Suzuki-Miyaura cross-couplings of n-alkylboronic acids with chiral vinyl iodides. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：7211 / 7212

页数：2

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