Practical, enantiospecific syntheses of 14,15-EET and leukotoxin B (vernolic acid)

被引：29

作者：

Falck, JR ^{[1
]}

Reddy, YK ^{[1
]}

Haines, DC ^{[1
]}

Reddy, KM ^{[1
]}

Krishna, UM ^{[1
]}

Graham, S ^{[1
]}

Murry, B ^{[1
]}

Peterson, JA ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Chem, Dallas, TX 75235 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 25期

关键词：

eicosanoids; epoxides; inversion reactions; asymmetric synthesis; biosynthesis;

D O I：

10.1016/S0040-4039(01)00694-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cytochrome P450BM3 and its F87V mutant were exploited for a convenient, laboratory scale (1 mmol) preparation of 14(S), 15(R)-epoxyeicosatrienoic acid [14(S),15(R)-EET] from arachidonic acid and (+)-leukotoxin B [(+)-12(S),13(R)-vernolic acid] from linoleic acid, respectively. Their enantiomers were accessed via a four-step chemical inversion. (C) 2001 Elsevier Science Ltd. Ail rights reserved.

引用

页码：4131 / 4133

页数：3

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