Synthesis and antifungal activities of novel 1,3-β-D-glucan synthase inhibitors.: Part 2

被引：12

作者：

Masubuchi, K

Okada, T

Kohchi, M

Murata, T

Tsukazaki, M

Kondoh, O

Yamazaki, T

Satoh, Y

Ono, Y

Tsukaguchi, T

Kobayashi, K

Ono, N

Inoue, T

Horii, I

Shimma, N

机构：

[1] Nippon Roche Res Ctr, Dept Chem, Kanagawa 2478530, Japan

[2] Nippon Roche Res Ctr, Dept Mycol, Kanagawa 2478530, Japan

[3] Nippon Roche Res Ctr, Dept Preclin Sci, Kanagawa 2478530, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(01)00178-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Highly potent 1,3-beta -D-glucan synthase inhibitors, 7b, 10a, 10b and 12, have been identified by the chemical modification of the ornithine residue of a fungicidal macrocyclic lipopeptidolactone, RO-09-3655 (1), isolated from the cultured broth of Deuteromycotinia spp. These compounds showed stronger antifungal activity against systemic candidiasis as well as pulmonary aspergillosis in mice, and less hepatotoxicity as compared with 1. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1273 / 1276

页数：4

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