Type 1 diabetes and gut microbiota: Friend or foe?

被引：42

作者：

Hu, Changyun ^{[1
]}

Wong, F. Susan ^{[2
]}

Wen, Li ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Internal Med, Endocrinol Sect, New Haven, CT 06510 USA

[2] Cardiff Univ, Sch Med, Inst Mol & Expt Med, Cardiff CF10 3AX, S Glam, Wales

来源：

PHARMACOLOGICAL RESEARCH | 2015年 / 98卷

关键词：

Type; 1; diabetes; Gut microbiota; NOD mice; Autoimmunity; HYDROLYZED CASEIN DIET; EARLY-LIFE; T-CELLS; ANTIBIOTIC-TREATMENT; LACTOCOCCUS-LACTIS; COMMENSAL BACTERIA; RISING INCIDENCE; COWS MILK; AUTOIMMUNE; ONSET;

D O I：

10.1016/j.phrs.2015.02.006

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Type 1 diabetes is a T cell-mediated autoimmune disease. Environmental factors play an important role in the initiation of the disease in genetically predisposed individuals. With the improved control of infectious disease, the incidence of autoimmune diseases, particularly type 1 diabetes, has dramatically increased in developed countries. Increasing evidence suggests that gut microbiota are involved in the pathogenesis of type 1 diabetes. Here we focus on recent advances in this field and provide a rationale for novel therapeutic strategies targeting gut microbiota for the prevention of type I diabetes. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：9 / 15

页数：7

共 111 条

[1]

Mining the Human Gut Microbiota for Effector Strains that Shape the Immune System [J].

Ahern, Philip P. ;

Faith, Jeremiah J. ;

Gordon, Jeffrey I. .

IMMUNITY, 2014, 40 (06) :815-823

[2]

Effects of a germ-free environment on gut immune regulation and diabetes progression in non-obese diabetic (NOD) mice [J].

Alam, C. ;

Bittoun, E. ;

Bhagwat, D. ;

Valkonen, S. ;

Saari, A. ;

Jaakkola, U. ;

Eerola, E. ;

Huovinen, P. ;

Hanninen, A. .

DIABETOLOGIA, 2011, 54 (06) :1398-1406

[3]

Allen-Vercoe Emma, 2012, Can J Gastroenterol, V26, P457

[4]

Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice [J].

Ansaria, Mohammed Javeed I. ;

Fiorina, Paolo ;

Dada, Shirine ;

Guleria, Indira ;

Ueno, Takuya ;

Yuan, Xueli ;

Trikudanathan, Subbulaxmi ;

Smith, R. Neal ;

Freeman, Gordon ;

Sayegh, Mohamed H. .

CLINICAL IMMUNOLOGY, 2008, 126 (02) :140-147

[5]

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation [J].

Arpaia, Nicholas ;

Campbell, Clarissa ;

Fan, Xiying ;

Dikiy, Stanislav ;

van der Veeken, Joris ;

deRoos, Paul ;

Liu, Hui ;

Cross, Justin R. ;

Pfeffer, Klaus ;

Coffer, Paul J. ;

Rudensky, Alexander Y. .

NATURE, 2013, 504 (7480) :451-+

[6]

Microbiota in autoimmunity and tolerance [J].

Atarashi, Koji ;

Honda, Kenya .

CURRENT OPINION IN IMMUNOLOGY, 2011, 23 (06) :761-768

[7]

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Shima, Tatsuichiro ;

Imaoka, Akemi ;

Kuwahara, Tomomi ;

Momose, Yoshika ;

Cheng, Genhong ;

Yamasaki, Sho ;

Saito, Takashi ;

Ohba, Yusuke ;

Taniguchi, Tadatsugu ;

Takeda, Kiyoshi ;

Hori, Shohei ;

Ivanov, Ivaylo I. ;

Umesaki, Yoshinori ;

Itoh, Kikuji ;

Honda, Kenya .

SCIENCE, 2011, 331 (6015) :337-341

[8]

Mechanisms of disease: The effect of infections on susceptibility to autoimmune and allergic diseases [J].

Bach, JF .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (12) :911-920

[9]

Defining a Healthy Human Gut Microbiome: Current Concepts, Future Directions, and Clinical Applications [J].

Backhed, Fredrik ;

Fraser, Claire M. ;

Ringel, Yehuda ;

Sanders, Mary Ellen ;

Sartor, R. Balfour ;

Sherman, Philip M. ;

Versalovic, James ;

Young, Vincent ;

Finlay, B. Brett .

CELL HOST & MICROBE, 2012, 12 (05) :611-622

[10]

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes [J].

Barrett, Jeffrey C. ;

Clayton, David G. ;

Concannon, Patrick ;

Akolkar, Beena ;

Cooper, Jason D. ;

Erlich, Henry A. ;

Julier, Cecile ;

Morahan, Grant ;

Nerup, Jorn ;

Nierras, Concepcion ;

Plagnol, Vincent ;

Pociot, Flemming ;

Schuilenburg, Helen ;

Smyth, Deborah J. ;

Stevens, Helen ;

Todd, John A. ;

Walker, Neil M. ;

Rich, Stephen S. .

NATURE GENETICS, 2009, 41 (06) :703-707

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