Cutaneous cancer stem cells:: β-catenin strikes again

被引:5
作者
Braun, Kristin M. [1 ]
机构
[1] Barts & London Queen Marys Sch Med & Dent, Ctr Cutaneous Res, Inst Cell & Mol Sci, London E1 2AT, England
基金
英国医学研究理事会;
关键词
D O I
10.1016/j.stem.2008.04.011
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Cancer stem cells (CSCs) are a subpopulation of tumor cells that retain properties of tissue-specific stem cells, including the ability to self-renew. In a recent article in Nature, Malanchi et al. (2008) identified a population of CD34(+) cells in epidermal tumors that require beta-catenin signaling to maintain a CSC phenotype.
引用
收藏
页码:406 / 408
页数:3
相关论文
共 10 条
[1]
Cancer stem cells in solid tumors [J].
Ailles, Laurie E. ;
Weissman, Irving L. .
CURRENT OPINION IN BIOTECHNOLOGY, 2007, 18 (05) :460-466
[2]
Prospective identification of tumorigenic breast cancer cells [J].
Al-Hajj, M ;
Wicha, MS ;
Benito-Hernandez, A ;
Morrison, SJ ;
Clarke, MF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988
[3]
β-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin [J].
Huelsken, J ;
Vogel, R ;
Erdmann, B ;
Cotsarelis, G ;
Birchmeier, W .
CELL, 2001, 105 (04) :533-545
[4]
Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling [J].
Malanchi, Ilaria ;
Peinado, Hector ;
Kassen, Deepika ;
Hussenet, Thomas ;
Metzger, Daniel ;
Chambon, Pierre ;
Huber, Marcel ;
Hohl, Daniel ;
Cano, Amparo ;
Birchmeier, Walter ;
Huelsken, Joerg .
NATURE, 2008, 452 (7187) :650-U12
[5]
Keratinocyte stem cells: targets for cutaneous carcinogens [J].
Morris, RJ .
JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (01) :3-8
[6]
Characterization and isolation of stem cell-enriched human hair follicle bulge cells [J].
Ohyama, M ;
Terunuma, A ;
Tock, CL ;
Radonovich, MF ;
Pise-Masison, CA ;
Hopping, SB ;
Brady, JN ;
Udey, MC ;
Vogel, JC .
JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (01) :249-260
[7]
Wnt signalling in stem cells and cancer [J].
Reya, T ;
Clevers, H .
NATURE, 2005, 434 (7035) :843-850
[8]
β-catenin and hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells [J].
Silva-Vargas, V ;
Lo Celso, C ;
Giangreco, A ;
Ofstad, T ;
Prowse, DM ;
Braun, KM ;
Watt, FM .
DEVELOPMENTAL CELL, 2005, 9 (01) :121-131
[9]
Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34 [J].
Trempus, CS ;
Morris, RJ ;
Bortner, CD ;
Cotsarelis, G ;
Faircloth, RS ;
Reece, JM ;
Tennant, RW .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2003, 120 (04) :501-511
[10]
Cancer stem cells: An old idea - A paradigm shift [J].
Wicha, MS ;
Liu, SL ;
Dontu, G .
CANCER RESEARCH, 2006, 66 (04) :1883-1890