Successful treatment of HTLV-1-associated acute adult T-cell leukaemia lymphoma by allogeneic bone marrow transplantation

被引:49
作者
Borg, A
Yin, JAL
Johnson, PRE
Tosswill, J
Saunders, M
机构
[1] MANCHESTER ROYAL INFIRM,UNIV DEPT CLIN HAEMATOL,MANCHESTER M13 9WL,LANCS,ENGLAND
[2] CENT PUBL HLTH LAB,VIRUS REFERENCE DIV,LONDON NW9 5HT,ENGLAND
[3] UNIV MANCHESTER,DEPT PATHOL SCI,DIV VIROL,MANCHESTER,LANCS,ENGLAND
关键词
HTLV-1; adult T-cell leukaemia lymphoma; allogeneic bone marrow transplantation;
D O I
10.1046/j.1365-2141.1996.02338.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
HTLV-1-associated acute adult T-cell leukaemia-lymphoma (ATL) is a highly aggressive malignant disorder with a median survival of 6 months or less. We describe an Afro-Caribbean female with very poor prognosis ATL who underwent chemotherapy with a 4d infusion schedule of cyclophosphamide, doxorubicin and etoposide, followed by successful allogeneic bone marrow transplantation (BMT) from her HTLV-1-negative histocompatibile sister. The patient remains in complete remission 23 months after BMT and has 100% donor haemopoiesis with no evidence of HTLV-1 infection on PCR testing. We suggest that allo-BMT can prolong disease-free survival or may even be curative in HTLV patients.
引用
收藏
页码:713 / 715
页数:3
相关论文
共 13 条
  • [1] BUNN PA, 1983, NEW ENGL J MED, V309, P257, DOI 10.1056/NEJM198308043090501
  • [2] CUMMING AM, 1992, HUM GENET, V89, P194
  • [3] GALLO RC, 1991, J INFECT DIS, V164, P234
  • [4] KAWANO F, 1985, CANCER-AM CANCER SOC, V55, P851, DOI 10.1002/1097-0142(19850215)55:4<851::AID-CNCR2820550424>3.0.CO
  • [5] 2-J
  • [6] LAURIA F, 1994, LEUKEMIA, V8, P724
  • [7] INFECTION OF DONOR LYMPHOCYTES WITH HUMAN T-LYMPHOTROPHIC VIRUS TYPE-1 (HTLV-I) FOLLOWING ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR HTLV-I POSITIVE ADULT T-CELL LEUKEMIA
    LJUNGMAN, P
    LAWLER, M
    ASJO, B
    BOGDANOVIC, G
    KARLSSON, K
    MALM, C
    MCCANN, SR
    RINGDEN, O
    GAHRTON, G
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 1994, 88 (02) : 403 - 405
  • [8] Shimoyama M., 1992, ADV ADULT T CELL LEU, P43
  • [9] MOLECULAR-BIOLOGY OF THE TYPE-I HUMAN T-CELL LEUKEMIA-VIRUS (HTLV-I) AND ADULT T-CELL LEUKEMIA
    SMITH, MR
    GREENE, WC
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (03) : 761 - 766
  • [10] SOBUE R, 1987, BONE MARROW TRANSPL, V2, P441