Prospects for a vaccine against the hepatitis C virus

被引：240

作者：

Houghton, M

Abrignani, S

机构：

[1] Chiron Corp, Emeryville, CA 94608 USA

[2] INGM, Natl Inst Mol Genet, I-20122 Milan, Italy

来源：

NATURE | 2005年 / 436卷 / 7053期

关键词：

D O I：

10.1038/nature04081

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

The recent discovery of natural immunity to the hepatitis C virus and vaccine efficacy in the chimpanzee challenge model has allowed optimism about the development of at least a partly effective vaccine against this heterogeneous pathogen that is responsible for much of the chronic liver disease around the world. The immune systems of some infected individuals can spontaneously clear the virus, whereas other people need treatment with antivirals that work partly by stimulating humoral and cellular immune responses. Therefore, therapeutic vaccine strategies are also being pursued to improve treatment outcome.

引用

收藏

页码：961 / 966

页数：6

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