Biologically active carbazole alkaloids from Murraya koenigii

被引：193

作者：

Ramsewak, RS

Nair, MG ^{[1
]}

Strasburg, GM

DeWitt, DL

Nitiss, JL

机构：

[1] Michigan State Univ, Dept Hort & Natl Food Safety, E Lansing, MI 48824 USA

[2] Michigan State Univ, Toxicol Ctr, Dept Food Sci & Human Nutr, E Lansing, MI 48824 USA

[3] Michigan State Univ, Dept Biochem, E Lansing, MI 48824 USA

[4] St Jude Childrens Res Hosp, Memphis, TN 38101 USA

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 1999年 / 47卷 / 02期

关键词：

Murraya koenigii; carbazole alkaloid; mahanimbine; murrayanol; mahanine; mosquitocidal; antimicrobial; antiinflammatory; antioxidant;

D O I：

10.1021/jf9805808

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The bioassay guided fractionation of the acetone extract of the fresh leaves of Murraya koenigii resulted in the isolation of three bioactive carbazole alkaloids, mahanimbine (1), murrayanol (2), and mahanine (3), as confirmed from their H-1 and C-13 NMR spectral data. Compound 2 showed an IC50 of 109 mu g/mL against hPGHS-1 and an IC50 of 218 mu g/mL against hPGHS-2 in antiinflammatory assays, while compound 1 displayed antioxidant activity at 33.1 mu g/mL. All three compounds were mosquitocidal and antimicrobial and exhibited topoisomerase I and II inhibition activities.

引用

页码：444 / 447

页数：4

共 15 条

[1]

[Anonymous], PROGR CHEM ORGANIC N

[2] Development and validation of fluorescence spectroscopic assays to evaluate antioxidant efficacy. Application to metal chelators [J].